Summative Diagnosis:
Cardiovascular Phenotype: Mutants can have dextracardia and complex congenital heart defects associated with heterotaxy, such as ambiguous atria (left atrial isomerism), transposition of the great arteries (TGA), overriding aorta/double outlet right ventricle (DORV), atrioventricular septal defect (AVSD), biventricular hypertrophy, and inferior vena cava (IVC) anomalies, including dual inferior vena cava
Noncardiovascular Phenotype: Situs inversus totalis, as well as heterotaxy with abnormal thoracic and abdominal organ situs anomalies, such as different combinations with dextrogastria, hypoplastic spleen, left lung isomerism, malaligned sternal vertebras. Kidney cyst and tracheal airway cilia are slow/dyskinetic/immotile.

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0190	Heterotaxy syndrome
0600	Double outlet right ventricle
0606	DORV + AVSD (AV canal)
0700	D-loop transposition of the great arteries
1100	Atrioventricular canal (endocardial cushion defect)
1432	Overriding aortic valve
2810	Inferior vena cava anomaly
4100	Skeletal, skin, muscle anomaly
4239	Left bronchial isomerism
4508	Polycystic kidney disease
4906	Non-cardiac abnormality
7505	Biventricular hypertrophy