Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hprt1tm1(Tek-lacZ)Rdr
Name:	hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Robert D Rosenberg
MGI ID:	MGI:2386181
Gene:	Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance:	Hprt1tm1(Tek-lacZ)Rdr page

Germline Transmission:	Earliest citation of germline transmission: J:62744
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a lacZ gene fused to 2.1 kb of Tek promoter sequences. The lacZ gene is expressed by the Tek promoter specifically in endothelial cells in the developing embryo and in the brain and kidney of adult animals. (J:62744)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:	1274 strains or lines available

Original:	J:62744 Evans V, et al., Targeting the Hprt locus in mice reveals differential regulation of Tie2 gene expression in the endothelium. Physiol Genomics. 2000 Mar 13;2(2):67-75
All:	1 reference(s)