Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rarbtm2.1Ipc
Name:	retinoic acid receptor, beta; targeted mutation 2.1, Pierre Chambon
MGI ID:	MGI:2386109
Synonyms:	RARbetaL-
Gene:	Rarb  Location: Chr14:5650540-6038924 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Alliance:	Rarbtm2.1Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:75134
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: The floxed fragment containing exons 9 and and 10 was excised from Rarbtm2Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the ligand binding domain and introduced a frameshift mutation. Neither isoform produced by the endogenous gene was detected in homozygous mutant mice via immunoblot analysis. (J:75134)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:	39 strains or lines available

Original:	J:75134 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene. Genesis. 2002 Feb;32(2):91-4
All:	2 reference(s)