Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Lrrk2tm3.1Mjff
Name:	leucine-rich repeat kinase 2; targeted mutation 3.1, The Michael J Fox Foundation
MGI ID:	MGI:5466853
Synonyms:	LRRK2-A2016T
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm3.1Mjff page

Germline Transmission:	Earliest citation of germline transmission: J:230329
Parent Cell Line:	JM8 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Humanized sequence) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to introduce an alanine to threonine (A2016T) substitution at codon 2016 of exon 41. An FRT-flanked neomycin cassette was introduced 400 bp downstream of exon 41. FLP recombinase mediated recombination removed the neo cassette. (J:230329)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:230329 Steger M, et al., Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. Elife. 2016;5:e12813
All:	5 reference(s)