Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ndufs4Gt(CB0524)Wtsi
Name:	NADH:ubiquinone oxidoreductase core subunit S4; gene trap CB0524, Wellcome Trust Sanger Institute
MGI ID:	MGI:3866986
Synonyms:	Ndufs4CB0524, Ndufs4GT
Gene:	Ndufs4  Location: Chr13:114424331-114524630 bp, - strand  Genetic Position: Chr13, 64.12 cM, cytoband D2.2
Alliance:	Ndufs4Gt(CB0524)Wtsi page

Mutant Cell Line:	CB0524
Germline Transmission:	Earliest citation of germline transmission: J:326310
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Hypomorph, Reporter) Mutation:    Insertion     Vector: pGT0lxfT1   Mutation details: A gene trap vector inserted into intron 1. A 50% reduction in both encoded mRNA transcript, as well as encoded protein abundance was shown in brain tissue of homozygous mice, resulting in a 25% reduction in protein activity in the hippocampus compared to controls. (J:326310) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select CB0524 CZ444367 (MGI Seq Detail) 5' RACE Chr13:114524494-114524613 bp (-) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 38 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndufs4 Mutation:	27 strains or lines available

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	2 reference(s)