Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lef1tm1Hhx
Name:	lymphoid enhancer binding factor 1; targeted mutation 1, Hai-Hui Xue
MGI ID:	MGI:5447957
Synonyms:	Lef1FL
Gene:	Lef1  Location: Chr3:130904120-131018005 bp, + strand  Genetic Position: Chr3, 60.78 cM
Alliance:	Lef1tm1Hhx page

Germline Transmission:	Earliest citation of germline transmission: J:189838
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 8. Flp-mediated recombination removed the neo cassette and left exons 7 and 8 were floxed. (J:189838, J:190675)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lef1 Mutation:	42 strains or lines available

Original:	J:189838 Zhou X, et al., Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J Immunol. 2012 Sep 15;189(6):2722-6
All:	23 reference(s)