Mef2ctm1.1(KOMP)Mbp
Targeted Allele Detail
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Symbol: |
Mef2ctm1.1(KOMP)Mbp |
Name: |
myocyte enhancer factor 2C; targeted mutation 1.1, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:5446144 |
Gene: |
Mef2c Location: Chr13:83652153-83815199 bp, + strand Genetic Position: Chr13, 43.68 cM
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Alliance: |
Mef2ctm1.1(KOMP)Mbp page
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IMPC: |
Mef2c gene page |
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Mutant Cell Lines: |
DEPD00527_3_B03, DEPD00527_3_C03 |
Germline Transmission: |
Earliest citation of germline transmission:
J:188991
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 654 starting at position 83740572 and ending at position 83741226 of Chromosome 13 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Subsequent cre expression excised this neomycin resistance cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:157064, J:188991)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mef2c Mutation: |
33 strains or lines available
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
2 reference(s) |
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