Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rptortm1Ahir
Name:	regulatory associated protein of MTOR, complex 1; targeted mutation 1, Atsushi Hirao
MGI ID:	MGI:5441589
Synonyms:	Raptorfl, Rptortm1Sama
Gene:	Rptor  Location: Chr11:119493731-119790402 bp, + strand  Genetic Position: Chr11, 83.96 cM, cytoband E2
Alliance:	Rptortm1Ahir page

Germline Transmission:	Earliest citation of germline transmission: J:188676
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and a second loxP site followed by an FRT flanked neo cassette were inserted in intron 2. Subsequent flp recombinase expression removed the neo selection cassette. (J:190434)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rptor Mutation:	115 strains or lines available

Original:	J:188676 Ohtani M, et al., Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production. J Immunol. 2012 May 15;188(10):4736-40
All:	8 reference(s)