Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fbn1tm1Itl
Name:	fibrillin 1; targeted mutation 1, inGenious Targeting Laboratory
MGI ID:	MGI:5439624
Synonyms:	Fbn1fneo
Gene:	Fbn1  Location: Chr2:125142514-125348417 bp, - strand  Genetic Position: Chr2, 61.38 cM, cytoband F
Alliance:	Fbn1tm1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:187484
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Quantitative RT-PCR confirmed the absence of transcript expression. (J:187484)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fbn1 Mutation:	171 strains or lines available

Original:	J:187484 Cook JR, et al., Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis. 2012 Aug;50(8):635-41
All:	1 reference(s)