Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nlgn3tm1.1Rhn
Name:	neuroligin 3; targeted mutation 1.1, Rene Hen
MGI ID:	MGI:5439286
Synonyms:	Neuroligin 3 tetO
Gene:	Nlgn3  Location: ChrX:100342785-100364956 bp, + strand  Genetic Position: ChrX, 43.95 cM
Alliance:	Nlgn3tm1.1Rhn page

Germline Transmission:	Earliest citation of germline transmission: J:159353
Parent Cell Line:	CSL3 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Flexible Accelerated STOP Tetracycline Operator (tetO)-knockin (FAST) was used to insert a construct containing a loxP site, FRT site, neo cassette, STOP, FRT site, tetracycline operator (tetO) and loxP site was inserted upstream of the translation initiation site. Flp-mediated recombination removed the neo/STOP cassette and left the tetO intact. Western blot analysis confirmed normal protein expression in the brain. (J:159353)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nlgn3 Mutation:	35 strains or lines available

Original:	J:159353 Tanaka KF, et al., Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol Psychiatry. 2010 Apr 15;67(8):770-3
All:	1 reference(s)