Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Il17atm1.1Lky
Name:	interleukin 17A; targeted mutation 1.1, Richard M Locksley
MGI ID:	MGI:5439016
Synonyms:	Smart-17A
Gene:	Il17a  Location: Chr1:20801129-20804720 bp, + strand  Genetic Position: Chr1, 6.45 cM, cytoband A
Alliance:	Il17atm1.1Lky page

Germline Transmission:	Earliest citation of germline transmission: J:187909
Parent Cell Line:	PC3 (ES Cell)
Strain of Origin:	129S4/SvJae-Tg(Prm-cre)70Og

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The 3' untranslated region (UTR) was modified to include a floxed neo cassette, an internal ribosomal entry site (IRES) and a non-signaling form of the human nerve growth factor (NGFR) gene. This results in IRES mediated translation of NGFR when the endogenous locus is activated. Cre-mediated recombination removed the neo cassette. (J:187909)

Generation of the Il17atm1.1Lky allele

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il17a Mutation:	22 strains or lines available

Original:	J:187909 Price AE, et al., Marking and quantifying IL-17A-producing cells in vivo. PLoS One. 2012;7(6):e39750
All:	7 reference(s)