Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Porcntm1.2Vdv
Name:	porcupine O-acyltransferase; targeted mutation 1, Ignatia B Van den Veyver
MGI ID:	MGI:5435557
Synonyms:	Porcn-ex3-7del
Gene:	Porcn  Location: ChrX:8060087-8072764 bp, - strand  Genetic Position: ChrX, 3.7 cM
Alliance:	Porcntm1.2Vdv page

Germline Transmission:	Earliest citation of germline transmission: J:186934
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S5/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 3 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 7. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exons 3 - 7. (J:186934)

Generation of Porcn targeted alleles

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Porcn Mutation:	18 strains or lines available

Original:	J:186934 Liu W, et al., Deletion of Porcn in mice leads to multiple developmental defects and models human focal dermal hypoplasia (Goltz syndrome). PLoS One. 2012;7(3):e32331
All:	1 reference(s)