Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Grm1Tg(p18A4.B)1352Szc
Name:	glutamate receptor, metabotropic 1; transgene insertion 1352, Suzie Chen
MGI ID:	MGI:5432227
Synonyms:	TG3
Gene:	Grm1  Location: Chr10:10561803-10958100 bp, - strand  Genetic Position: Chr10, 3.44 cM, cytoband A2
Alliance:	Grm1Tg(p18A4.B)1352Szc page

Strain of Origin:

Not Specified

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Mutation details: The transgene contained a 2 kb segment of human cosmid p18A4 (known as Clone B; abbreviated here as p18A4.B). Line 1352 contains 3 copies of the transgene that insert into intron 3 and result in a 70 kb deletion within intron 3. Western blot analysis confirmed ectopic expression in melanoma tumors. (J:11894, J:83183) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grm1 Mutation:	78 strains or lines available

Original:	J:32786 Chen S, et al., Spontaneous melanocytosis in transgenic mice. J Invest Dermatol. 1996 May;106(5):1145-51
All:	7 reference(s)