Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpm6atm1.1Tahi
Name:	glycoprotein m6a; targeted mutation 1.1, Tatsumi Hirata
MGI ID:	MGI:5427086
Synonyms:	M6a-
Gene:	Gpm6a  Location: Chr8:55407878-55513906 bp, + strand  Genetic Position: Chr8, 29.33 cM, cytoband B3.2
Alliance:	Gpm6atm1.1Tahi page

Germline Transmission:	Earliest citation of germline transmission: J:184737
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a floxed PGK-neomycin selection cassette. The selection cassette was removed from properly targeted mice by cr excision. Removal of exon 2 causes a downstream frame shift and only short, non-functional, N-terminal peptides ar produced. (J:184737)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

3 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpm6a Mutation:	27 strains or lines available

Original:	J:184737 Sato Y, et al., Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a. Dev Neurobiol. 2011 Sep;71(9):733-46
All:	3 reference(s)