Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(SRY-cre)1Svs
Name:	transgene insertion 1, David W Silversides
MGI ID:	MGI:5426227
Synonyms:	pSRYp[4.6kb]-Cre
Transgene:	Tg(SRY-cre)1Svs  Location: unknown
Alliance:	Tg(SRY-cre)1Svs page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(SRY-cre)1Svs expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note pig, domestic SRY   Mutation details: A construct in which the 4.6 kb porcine SRY promoter drives expression of the cre recombinase sequence was microinjected into male pronuclei of single-celled FVB/N embryos. A second construct encoding a tyrosinase minigene was co-injected to facilitate identification of transgenic animals. Pigmented founders were bred to wild-type FVB/N mice to ensure single integration sites. Three founder lines were obtained and crossed to cre reporter ROSA-YFP mice to analyze cre activity in newborn tissues from double transgenic mice. The three lines displayed similar results and one line was propagated for further studies. (J:184604)

Activity:	Tissue activity of this recombinase allele
Driver:	SRY (pig, domestic) Summary of all recombinase alleles driven by SRY.

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:184604 Silversides DW, et al., Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage. Dev Dyn. 2012 Jul;241(7):1192-204
All:	1 reference(s)