Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gli3tm1.1Zllr
Name:	GLI-Kruppel family member GLI3; targeted mutation 1.1, Rolf Zeller
MGI ID:	MGI:5425255
Synonyms:	Gli3f
Gene:	Gli3  Location: Chr13:15638308-15904611 bp, + strand  Genetic Position: Chr13, 5.43 cM, cytoband A2
Alliance:	Gli3tm1.1Zllr page

Germline Transmission:	Earliest citation of germline transmission: J:184012
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A lox511 site, loxP site and FRT flanked neo cassette were inserted upstream of exon 11 and a loxP site, a splice acceptor site, IRES site, EGFP cassette, F3 flanked hygromycin cassette and lox2272 site were inserted downstream of exon 15. Flp mediated recombination removed the neo and hygromycin cassettes. (J:184012)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli3 Mutation:	80 strains or lines available

Original:	J:184012 Lopez-Rios J, et al., GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell. 2012 Apr 17;22(4):837-48
All:	2 reference(s)