Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rapgef3tm1.1Geno
Name:	Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.1, Genoway
MGI ID:	MGI:5318394
Gene:	Rapgef3  Location: Chr15:97642651-97665853 bp, - strand  Genetic Position: Chr15, 53.74 cM
Alliance:	Rapgef3tm1.1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:182701
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 3-6 floxed. (J:182701)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:	45 strains or lines available

Original:	J:182701 Yang Y, et al., EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron. 2012 Feb 23;73(4):774-88
All:	5 reference(s)