Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il10tm1Hbo
Name:	interleukin 10; targeted mutation 1, Hicham Bouabe
MGI ID:	MGI:5301907
Synonyms:	ITIG
Gene:	Il10  Location: Chr1:130947582-130952711 bp, + strand  Genetic Position: Chr1, 56.89 cM
Alliance:	Il10tm1Hbo page

Germline Transmission:	Earliest citation of germline transmission: J:179239
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Reporter) Mutation:    Insertion   Mutation details: An IRES-EGFP sequence was introduced immediately after the stop codon in exon 5. This was followed by a floxed neo selection cassette. The selection cassette was excised by crossing mice to Tg(CMV-cre)1Cgn mice. EGFP expression was observed in T cells but not in B cells. (J:179239)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il10 Mutation:	44 strains or lines available

Original:	J:179239 Bouabe H, et al., Novel highly sensitive IL-10-beta-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo. J Immunol. 2011 Sep 15;187(6):3165-76
All:	1 reference(s)