Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ifnar1tm1.1Syfu
Name:	interferon (alpha and beta) receptor 1; targeted mutation 1.1, Serge Y Fuchs
MGI ID:	MGI:5301423
Synonyms:	Ifnar1SA, mIFNAR1S526A
Gene:	Ifnar1  Location: Chr16:91282126-91304329 bp, + strand  Genetic Position: Chr16, 52.98 cM
Alliance:	Ifnar1tm1.1Syfu page

Germline Transmission:	Earliest citation of germline transmission: J:178406
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: Exon 11 was replaced with a floxed neo cassette and a modified exon 11 in which nucleotide substitution results in the amino acid substitution of alanine for serine at position 526 (S526A). Cre-mediated recombination removed the neo cassette. (J:178406)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ifnar1 Mutation:	59 strains or lines available

Original:	J:178406 Zheng H, et al., Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis. Blood. 2011 Oct 6;118(14):4003-6
All:	11 reference(s)