Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ighmtm1Bhe
Name:	immunoglobulin heavy constant mu; targeted mutation 1, Birgitta Heyman
MGI ID:	MGI:5297544
Synonyms:	Cmu13
Gene:	Ighm  Location: Chr12:113382446-113386350 bp, - strand  Genetic Position: Chr12, 62.1 cM, cytoband F1-2
Alliance:	Ighmtm1Bhe page

Germline Transmission:	Earliest citation of germline transmission: J:177421
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Single point mutation   Mutation details: A C to T point mutation was introduced into the gene coding for the third C domain of the mu-heavy chain causing the amino acid encoded by codon 436 to change from proline to serine. A floxed neomycin was inserted as well. This neo cassette was subsequently excised from correctly targeted mice. (J:177421, J:178135, J:178136)

Generation of the Ighmtm1Bhe allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ighm Mutation:	55 strains or lines available

Original:	J:177421 Rutemark C, et al., Requirement for complement in antibody responses is not explained by the classic pathway activator IgM. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E934-42
All:	4 reference(s)