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Sox2tm1(cre/ERT2)Hoch
Targeted Allele Detail
Nomenclature
Symbol: Sox2tm1(cre/ERT2)Hoch
Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger
MGI ID: MGI:5295990
Synonyms: Sox2-CreER
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177655
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsA targeting construct encoding a cre recombinase/mutated estrogen ligand binding-domain (cre/ERT2) fusion sequence and an Frt-flanked neo cassette was targeted to the Sox2 locus in V6.5 ES cells, so that cre was under control of endogenous Sox2 regulatory elements. Chimeric mice were bred to 129/SvJae wild-type animals to test for germline transmission and to establish stable lines. (J:177655)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sox2     Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  23 strains or lines available
References
Original:  J:177655 Arnold K, et al., Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory