Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmprss11dtm1Bug
Name:	transmembrane protease, serine 11d; targeted mutation 1, Thomas H Bugge
MGI ID:	MGI:5293641
Gene:	Tmprss11d  Location: Chr5:86450713-86521246 bp, - strand  Genetic Position: Chr5, 43.56 cM
Alliance:	Tmprss11dtm1Bug page

Germline Transmission:	Earliest citation of germline transmission: J:175364
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inserted expressed sequence, Reporter) Mutation:    Insertion   Mutation details: A MICER vector (MHPN265D14) was used to insert an inverted neo cassette, a TYR1-HPRT construct, and a genomic fragment containing exons 4 and 5, after exon 5 of the gene. This insertion introduces a frameshift mutation. RT-PCR analysis showed the expression of a mutant transcript containing the duplicated exons. (J:175364)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmprss11d Mutation:	34 strains or lines available

Original:	J:175364 Sales KU, et al., Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT. PLoS One. 2011;6(8):e23261
All:	1 reference(s)