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Hoxb1tm1.1Mist
Targeted Allele Detail
Nomenclature
Symbol: Hoxb1tm1.1Mist
Name: homeobox B1; targeted mutation 1.1, Michele Studer
MGI ID: MGI:5287678
Synonyms: Hoxb1null, Hoxb1 null
Gene: Hoxb1  Location: Chr11:96256578-96259082 bp, + strand  Genetic Position: Chr11, 59.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82809
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted into the Hoxb1 locus upstream of the r4 enhancer. A loxP-flanked neo cassette was inserted into intron 1. Internal to the first two loxP sites, two heterospecific Frt sites were also inserted such that by recombinase mediated cassette exchange, exogenous sequences could be knocked into Hoxb1. Electroporation of a cre-expressing plasmid into an ES cell clone containing the modified locus resulted in excision of the regions between the different combinations of loxP sites. Deletion of the region between the proximal and distal loxP sites produced the Hoxb1null allele. (J:197162)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxb1 Mutation:  18 strains or lines available
References
Original:  J:197162 Di Bonito M, et al., Assembly of the auditory circuitry by a Hox genetic network in the mouse brainstem. PLoS Genet. 2013;9(2):e1003249
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory