Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Lgr4tm1(cre/ERT2)Cle
Name:	leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1, Hans Clevers
MGI ID:	MGI:5285689
Synonyms:	Lgr4GFP-ires-CreERT2
Gene:	Lgr4  Location: Chr2:109747992-109844602 bp, + strand  Genetic Position: Chr2, 56.65 cM
Alliance:	Lgr4tm1(cre/ERT2)Cle page

Germline Transmission:	Earliest citation of germline transmission: J:174842
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase, Reporter) Inducer:    tamoxifen Mutation:    Insertion   Lgr4tm1(cre/ERT2)Cle expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Lgr4 (MGI:1891468)     A GFP, ires, cre/ERT2 fusion were inserted downstream of the translation initiation site. (J:174842)

Activity:	Tissue activity of this recombinase allele
Driver:	Lgr4 (mouse) Summary of all recombinase alleles driven by Lgr4. Comparative matrix view of recombinase activities Alliance mouse Lgr4 gene page

In Mice Carrying this Mutation:

43 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr4 Mutation:	94 strains or lines available

Original:	J:174842 de Lau W, et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Aug 18;476(7360):293-7
All:	5 reference(s)