Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	H2-Ab1b-tm1Koni
Name:	histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Pandelakis A Koni
MGI ID:	MGI:2384629
Synonyms:	H2-Ab1tm1Koni, I-AB-flox, iabneo, MHCIIfl
Gene:	H2-Ab1  Location: Chr17:34482201-34488392 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-Ab1b-tm1Koni page

Germline Transmission:	Earliest citation of germline transmission: J:75115
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A construct, in which the first coding exon was flanked by an upstream floxed neo cassette and a downstream loxP site, was integrated via homologous recombination. Flow cytometric analysis of splenocytes showed that the insertion of the loxP sites and neo cassette did not affect MHC-II surface expression. (J:75115)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:	81 strains or lines available

Original:	J:75115 Hashimoto K, et al., A conditional null allele of the major histocompatibility IA-beta chain gene. Genesis. 2002 Feb;32(2):152-3
All:	71 reference(s)