Fshrtm1Saco
Targeted Allele Detail
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Symbol: |
Fshrtm1Saco |
Name: |
follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi |
MGI ID: |
MGI:2384087 |
Synonyms: |
FORKO, Fshr-, FSH-R- |
Gene: |
Fshr Location: Chr17:89292380-89508103 bp, - strand Genetic Position: Chr17, 58.76 cM, cytoband E5
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Alliance: |
Fshrtm1Saco page
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Abnormal sperm morphology in Fshrtm1Saco/Fshrtm1Saco mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:50933
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The insertion of a neomycin selection cassette deleted exon 1. Northern blot analysis of testicular and ovarian RNA showed that the deletion was sufficient for abbrogating the expression of all known isoforms. The absence of functional protein in homozygous mutant mice was confirmed by lableled ligand binding assays of testis.
(J:50933)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fshr Mutation: |
49 strains or lines available
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Original: |
J:50933 Dierich A, et al., Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13612-7 |
All: |
35 reference(s) |
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