Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ercc1tm1Jhjh
Name:	excision repair cross-complementing rodent repair deficiency, complementation group 1; targeted mutation 1, Jan H J Hoeijmakers
MGI ID:	MGI:2183944
Synonyms:	Ercc1-
Gene:	Ercc1  Location: Chr7:19079016-19090449 bp, + strand  Genetic Position: Chr7, 9.6 cM
Alliance:	Ercc1tm1Jhjh page

Germline Transmission:	Earliest citation of germline transmission: J:41161
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette. Expression analysis showed an absence of transcript in mouse embryonic fibroblasts derived from homozygous mutant mice. Further analysis showed that transcription of the antisense gene was unaffected by the targeting event. (J:41161)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ercc1 Mutation:	27 strains or lines available

Original:	J:41161 Weeda G, et al., Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol. 1997 Jun 1;7(6):427-39
All:	47 reference(s)