Thrbtm2Few
Targeted Allele Detail
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Symbol: |
Thrbtm2Few |
Name: |
thyroid hormone receptor beta; targeted mutation 2, Frederic E Wondisford |
MGI ID: |
MGI:2183367 |
Synonyms: |
TRbetadelta337T |
Gene: |
Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
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Alliance: |
Thrbtm2Few page
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Germline Transmission: |
Earliest citation of germline transmission:
J:77623
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The deletion of 3 base pairs (GRCm39:chr14:4439427_4439429delGTG, p.T337del) in exon 9, corresponding to a deletion that results in thyroid horomone resistance in humans, was introduced via site-directed mutagenesis along with a neomycin selection cassette inserted into intron 8. The mutation affects the ligand-binding domain in the encoded peptide, which is common to both isoforms produced from this locus.
(J:77623)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Thrb Mutation: |
39 strains or lines available
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Original: |
J:77623 Hashimoto K, et al., An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3998-4003 |
All: |
7 reference(s) |
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