Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Clcn2tm1Tjj
Name:	chloride channel, voltage-sensitive 2; targeted mutation 1, Thomas J Jentsch
MGI ID:	MGI:2183261
Synonyms:	Clcn2-
Gene:	Clcn2  Location: Chr16:20521714-20536496 bp, - strand  Genetic Position: Chr16, 12.5 cM
Alliance:	Clcn2tm1Tjj page

Germline Transmission:	Earliest citation of germline transmission: J:68137
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 3 and all of exons 4 through 7 were replaced with a neomycin selection cassette. The deleted region encoded transmembrane domains 2 through 6. Truncated transcript was detected by Northern blot analysis using 5' and neo probes and undetected using a 3' probe. Protein was shown to be absent in homozygous mutant mice via Western blot analysis. (J:68137)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clcn2 Mutation:	40 strains or lines available

Original:	J:68137 Bosl MR, et al., Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. EMBO J. 2001 Mar 15;20(6):1289-99
All:	13 reference(s)