Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syt1tm2Sud
Name:	synaptotagmin I; targeted mutation 2, Thomas C Sudhof
MGI ID:	MGI:2180146
Gene:	Syt1  Location: Chr10:108333511-108846843 bp, - strand  Genetic Position: Chr10, 56.52 cM
Alliance:	Syt1tm2Sud page

Germline Transmission:	Earliest citation of germline transmission: J:76452
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Applicable) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into intron 1 via homologous recombination and results in a normal protein product. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression and enzyme assays demonstrated that the phospholipid- and syntaxin-binding ability of the protein remained intact. (J:76452)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syt1 Mutation:	39 strains or lines available

Original:	J:76452 Fernandez-Chacon R, et al., Synaptotagmin I functions as a calcium regulator of release probability. Nature. 2001 Mar 1;410(6824):41-9
All:	2 reference(s)