Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Prdm5Gt(AV0702)Wtsi Name: PR domain containing 5; gene trap AV0702, Wellcome Trust Sanger Institute MGI ID: MGI:3853086 Synonyms: Prdm5lacZ Gene: Prdm5  Location: Chr6:65755972-65913994 bp, + strand  Genetic Position: Chr6, 30.32 cM, cytoband C1 Alliance: Prdm5Gt(AV0702)Wtsi page

Reduced bone formation in Prdm5Gt(AV0702)Wtsi/Prdm5Gt(AV0702)Wtsi mice Show the 1 phenotype image(s) involving this allele.

Mutant Cell Line:	AV0702
Germline Transmission:	Earliest citation of germline transmission: J:185118
Parent Cell Line:	E14TG2a.4 (ES Cell)
Strain of Origin:	129P2/OlaHsd
Project Collection:	Sanger Inst. Gene Trap Res.

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: pGT0lxr   Mutation details: The gene tarp cassette inserted in intron 2. Protein expression is reduced in homozygous embryonic fibroblasts to at most 10% that in wild-type cells. In adult organs from homozygous mice, except for brain, testis and lung, expression is reduced by at least 85 percent. Expression of the fusion reporter protein is seen in osteoblastic compartments. (J:185118) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select AV0702 CL866216 (MGI Seq Detail) 5' RACE Chr6:65756009-65771366 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 25 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

Generation of the Prdm5Gt(AV0702)Wtsi allele

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prdm5 Mutation:	48 strains or lines available

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	4 reference(s)