Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Tph2tm1.1Kpl
Name:	tryptophan hydroxylase 2; targeted mutation 1.1, Klaus-Peter Lesch
MGI ID:	MGI:3851253
Synonyms:	Tph2flox
Gene:	Tph2  Location: Chr10:114914546-115020927 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance:	Tph2tm1.1Kpl page

Germline Transmission:	Earliest citation of germline transmission: J:150637
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 5 and a floxed neo cassette was inserted downstream of exon 5. Transient cre expression in ES cells removed the neo cassette leaving exon 5 floxed. (J:150637)

In Mice Carrying this Mutation:

41 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph2 Mutation:	41 strains or lines available

Original:	J:150637 Gutknecht L, et al., Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. J Neural Transm. 2008 Aug;115(8):1127-32
All:	8 reference(s)