Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cdc20tm1Pzg
Name:	cell division cycle 20; targeted mutation 1, Pumin Zhang
MGI ID:	MGI:3851131
Synonyms:	Cdc20AAA-flox-neo
Gene:	Cdc20  Location: Chr4:118290098-118294540 bp, - strand  Genetic Position: Chr4, 54.61 cM
Alliance:	Cdc20tm1Pzg page

Germline Transmission:	Earliest citation of germline transmission: J:150421
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Two charged residues (K129 and R132) and one proline (P137) in the motif for Mad2 binding were changed to alanine and a floxed neo and kan resistance cassette was inserted in intron 3 via homologous recombination. A truncated protein is expressed from this allele. (J:150421)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc20 Mutation:	30 strains or lines available

Original:	J:150421 Li M, et al., Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice. J Cell Biol. 2009 Jun 15;185(6):983-94
All:	1 reference(s)