Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cebpbtm1.1Acle
Name:	CCAAT/enhancer binding protein beta; targeted mutation 1.1, Achim Leutz
MGI ID:	MGI:3849861
Synonyms:	c/ebpbetaL, LIP k.i.
Gene:	Cebpb  Location: Chr2:167530835-167532338 bp, + strand  Genetic Position: Chr2, 87.58 cM
Alliance:	Cebpbtm1.1Acle page

Germline Transmission:	Earliest citation of germline transmission: J:150006
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Dominant negative) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding sequence was replaced with one encoding a truncated and dominant inhibitory isoform followed by a floxed neo cassette. Nucleotides 91 through 550 encoding the long transactivating transcript (LAP*) and N termini are deleted. Only the short repressive transcript is produced. Germ line, cre mediated recombination removed the neo cassette. (J:150006)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:	23 strains or lines available

Original:	J:150006 Smink JJ, et al., Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB. EMBO J. 2009 Jun 17;28(12):1769-81
All:	5 reference(s)