Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Atoh1tm1(cre/ERT2)Mhos
Name:	atonal bHLH transcription factor 1; targeted mutation 1, Mikio Hoshino
MGI ID:	MGI:3849084
Synonyms:	Atoh1CreERn, Atoh1null
Gene:	Atoh1  Location: Chr6:64706109-64708229 bp, + strand  Genetic Position: Chr6, 30.03 cM
Alliance:	Atoh1tm1(cre/ERT2)Mhos page

Germline Transmission:	Earliest citation of germline transmission: J:149533
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Atoh1tm1(cre/ERT2)Mhos expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Atoh1 (MGI:104654)   Mutation details: The Atoh1 locus was targeted with a vector that replaced the open-reading frame (ORF) of the gene with the sequence encoding cre recombinase fused to a mutated estrogen ligand-binding domain (ERT2), resulting in a null allele. (J:149533)

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Alliance mouse Atoh1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atoh1 Mutation:	36 strains or lines available

Original:	J:149533 Fujiyama T, et al., Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 2009 Jun;136(12):2049-58
All:	10 reference(s)