Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptgs2tm3Fun
Name:	prostaglandin-endoperoxide synthase 2; targeted mutation 3, Colin D Funk
MGI ID:	MGI:3846762
Synonyms:	COX-2Neo
Gene:	Ptgs2  Location: Chr1:149975851-149983978 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Alliance:	Ptgs2tm3Fun page

Germline Transmission:	Earliest citation of germline transmission: J:148699
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A floxed neo cassette was inserted into intron 9 via homologous recombination. Western blot analysis confirmed decreased protein expression in unstimulated and stimulated macrophages and endothelial cells from homozygous mice. (J:148699)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:	72 strains or lines available

Original:	J:148699 Seta F, et al., Renal and cardiovascular characterization of COX-2 knockdown mice. Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1751-60
All:	3 reference(s)