Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tlx2tm1.1(cre)Rpk
Name:	T cell leukemia, homeobox 2; targeted mutation 1.1, Raj P Kapur
MGI ID:	MGI:3846678
Synonyms:	Hox11L1-Cre
Gene:	Tlx2  Location: Chr6:83045306-83047206 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband C3-D1
Alliance:	Tlx2tm1.1(cre)Rpk page

Germline Transmission:	Earliest citation of germline transmission: J:148830
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Tlx2tm1.1(cre)Rpk expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tlx2 (MGI:1350935)   Mutation details: Part of exon 1 downstream of the translation initiation site was replaced with cre and a floxed neo cassette. The cre cassette was spontaneously excised. (J:148830)

Activity:	Tissue activity of this recombinase allele
Driver:	Tlx2 (mouse) Summary of all recombinase alleles driven by Tlx2. Alliance mouse Tlx2 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tlx2 Mutation:	12 strains or lines available

Original:	J:148830 Kapur RP, et al., Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice. Pediatr Dev Pathol. 2005 Mar-Apr;8(2):148-61
All:	2 reference(s)