Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccr6tm1(EGFP)Irw
Name:	C-C motif chemokine receptor 6; targeted mutation 1, Ifor R Williams
MGI ID:	MGI:2179543
Synonyms:	CCR6-, CCR6-GFP
Gene:	Ccr6  Location: Chr17:8454875-8475973 bp, + strand  Genetic Position: Chr17, 4.9 cM, cytoband A1
Alliance:	Ccr6tm1(EGFP)Irw page

Germline Transmission:	Earliest citation of germline transmission: J:73935
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A self-excising cre-neomycin resistance cassette replaced 213 bp of coding sequence at the 5' end of the gene, and placed the open reading frame of EGFP, followed by the late SV40 polyadenylation signal, inframe with upstream sequences. The B cell lineage expression pattern from this allele visualized using EGFP matches that of wild-type gene expression previously described using a mouse-specific monoclonal antibody. (J:73935)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccr6 Mutation:	36 strains or lines available

Original:	J:73935 Kucharzik T, et al., CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse. Eur J Immunol. 2002 Jan;32(1):104-12
All:	21 reference(s)