Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krt10M1Btlr
Name:	keratin 10; mutation 1, Bruce Beutler
MGI ID:	MGI:3842434
Synonyms:	Rough-fur
Gene:	Krt10  Location: Chr11:99276080-99280190 bp, - strand  Genetic Position: Chr11, 62.92 cM
Alliance:	Krt10M1Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: This mutation was discovered by its visible phenotype in progeny of a mutagenized male mouse. Sequence analysis of all the genes in the keratin gene cluster revealed an A to T transversion at nucleotide position 547 of the keratin 10 gene, in the first of the gene's eight exons, that results in replacement of a highly conserved glutamic acid by valine at amino acid position 172 of the keratin protein (E172V), in the first linker domain. (J:147340) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt10 Mutation:	32 strains or lines available

Original:	J:147340 Du X, et al., Record for "Rough-fur" updated April 14th, 2009. MGI Direct Data Submission. 2009;
All:	1 reference(s)