Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gata4tm1.1Jmol
Name:	GATA binding protein 4; targeted mutation 1.1, Jeffery D Molkentin
MGI ID:	MGI:5141274
Synonyms:	Gata4-S105A, S105A
Gene:	Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM
Alliance:	Gata4tm1.1Jmol page

Germline Transmission:	Earliest citation of germline transmission: J:174537
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted Mutation:    Insertion   Mutation details: Point mutations were introduced to change serine 105 into alanine and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of S105 phosphorylated protein and presence of non-phosphorylated protein. (J:174537)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:	36 strains or lines available

Original:	J:174537 van Berlo JH, et al., Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12331-6
All:	2 reference(s)