Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mecp2tm3.1Jae
Name:	methyl CpG binding protein 2; targeted mutation 3.1, Rudolf Jaenisch
MGI ID:	MGI:3840525
Synonyms:	Mecp2S421A;S424A
Gene:	Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance:	Mecp2tm3.1Jae page

Germline Transmission:	Earliest citation of germline transmission: J:147157
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Exons 3 and 4 were replaced by a floxed neo/STOP cassette and exons containing nucleotide substitutions that result in the amino acid substitutions of alanine for serine at positions 421 and 424 (S421A;S424A). Cre-mediated recombination was used to remove the neo/STOP cassette. (J:147157)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:	38 strains or lines available

Original:	J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7
All:	4 reference(s)