Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mecp2tm2Jae
Name:	methyl CpG binding protein 2; targeted mutation 2, Rudolf Jaenisch
MGI ID:	MGI:3840524
Synonyms:	LSL-Mecp2S80A
Gene:	Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance:	Mecp2tm2Jae page

Germline Transmission:	Earliest citation of germline transmission: J:147157
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Single point mutation   Mutation details: Exons 3 and 4 were replaced by a floxed neo/STOP cassette, a modified exon 3 with a G to T point mutation that results in an amino acid substitution of serine with alanine at position 80, and a normal exon 4. (J:147157)

Generation of the Mecp2tm2Jae allele

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:	38 strains or lines available

Original:	J:147157 Tao J, et al., Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7
All:	1 reference(s)