Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Tbx1tm1Bld Name: T-box 1; targeted mutation 1, Antonio Baldini MGI ID: MGI:2179136 Synonyms: Tbx1-, Tbx1lacZ Gene: Tbx1  Location: Chr16:18399729-18409412 bp, - strand  Genetic Position: Chr16, Syntenic Alliance: Tbx1tm1Bld page

Cleft palate, absent thymus and ear and cardiovascular abnormalities in Tbx1tm1Bld/Tbx1tm1Bld mice Show the 5 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:67409
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An IRES-lacZ reporter gene followed by a loxP-flanked neomycin resistance cassette was inserted into exon 5, which encodes part of the T box domain resulting in a functionally null allele. (J:67409)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	296 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	46 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:	34 strains or lines available

Original:	J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
All:	65 reference(s)