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Tead2tm1a(EUCOMM)Hmgu
Targeted Allele Detail
Nomenclature
Symbol: Tead2tm1a(EUCOMM)Hmgu
Name: TEA domain family member 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5052429
Gene: Tead2  Location: Chr7:45215753-45233636 bp, + strand  Genetic Position: Chr7, 29.19 cM, cytoband B5
Mutation
origin
Mutant Cell Lines:  HEPD0745_4_A09, HEPD0745_4_A10, HEPD0745_4_A11, HEPD0745_4_B10, HEPD0745_4_B12, HEPD0745_4_C12, HEPD0745_4_D09, HEPD0745_4_D10, HEPD0745_4_D11, HEPD0745_4_D12, HEPD0745_4_E11, HEPD0745_4_F09, HEPD0745_4_F11, HEPD0745_4_F12, HEPD0745_4_G10, HEPD0745_4_G11, HEPD0745_4_G12, HEPD0745_4_H09, HEPD0745_4_H10
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 45217537 of Chromosome 7 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 45218423. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157065)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Tead2 Mutation:  20 strains or lines available
References
Original:  J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory