Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Inpp5del20
Name:	inositol polyphosphate-5-phosphatase D; early lethal
MGI ID:	MGI:5050823
Synonyms:	Ship1el20
Gene:	Inpp5d  Location: Chr1:87548034-87648229 bp, + strand  Genetic Position: Chr1, 44.44 cM, cytoband C5
Alliance:	Inpp5del20 page

Strain of Origin:

129

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: A T to C transition was found at nucleotide position 2099 (Genbank NM_010566) in ENU mutant mice. This should cause an isoleucine to threonine change at amino acid residue 641. An in-vitro 5'-phosphatase assay demonstrated reduced enzyme activity as compared to un-mutated controls. Protein levels were reduced in Western blots as were mRNA levels by qRT-PCR. (J:173266)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Inpp5d Mutation:	93 strains or lines available

Original:	J:173266 Nguyen NY, et al., An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood. 2011 May 19;117(20):5362-71
All:	1 reference(s)