Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Wnt3atm1.1(cre)Mull
Name:	wingless-type MMTV integration site family, member 3A; targeted mutation 1, Ulrich Mueller
MGI ID:	MGI:5014206
Synonyms:	Wnt3a-IRES-Cre
Gene:	Wnt3a  Location: Chr11:59138859-59181578 bp, - strand  Genetic Position: Chr11, 37.17 cM
Alliance:	Wnt3atm1.1(cre)Mull page

Germline Transmission:	Earliest citation of germline transmission: J:151755
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a
Project Collection:	Neuroscience Blueprint cre

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Wnt3atm1.1(cre)Mull expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Wnt3a (MGI:98956)   Mutation details: A targeting vector was designed to insert an IRES-Cre cassette followed by an FRT-flanked PGK-Neo cassette into the 3' region of the wingless-related MMTV integration site 3A (Wnt3a) locus. This construct was electroporated into C57BL/6-derived Bruce4 embryonic stem (ES) cells. Chimeric mice were bred to albino B6(Cg)-Tyrc-2J/J mice. The resulting Wnt3a-IRES-Cre mutant mice were then bred to C57BL/6J inbred mice for many generations. At some point, Wnt3a-IRES-Cre mutant mice were bred with FLPe-expressing mice on a C57BL/6 congenic background thereby removing the FLPe-expressing transgene. (J:151755)

Activity:	Tissue activity of this recombinase allele
Driver:	Wnt3a (mouse) Summary of all recombinase alleles driven by Wnt3a. Comparative matrix view of recombinase activities Alliance mouse Wnt3a gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wnt3a Mutation:	25 strains or lines available

Original:	J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009;
All:	9 reference(s)