Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol: Notch1tm4(cre)Rko Name: notch 1; targeted mutation 4, Raphael Kopan MGI ID: MGI:5009236 Synonyms: N1::Crehi, NIP::CreHI, Notch1::creHi Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM Alliance: Notch1tm4(cre)Rko page

Embryonic lethality in Notch1tm2Rko/Notch1tm4(cre)Rko embryos due to the failure of angiogenic remodeling Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:171829
Parent Cell Line:	SCC10 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Recombinase) Mutations:    Insertion, Intragenic deletion   Notch1tm4(cre)Rko expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Notch1 (MGI:97363)   Mutation details: The Notch1 intracellular domain (IC) is replaced by the cre recombinase sequence and includes the SV40 3' UTR polyA signal while introducing a single nucleotide variation (SNV) at C5178A to facilitate genotyping. This allele does not have the 6xMyc tag present in the Notch1tm3(cre)Rko allele, and displays enhanced activity relative to that allele. (J:171829, J:172930)

Generation of the Notch1tm4(cre)Rko allele

Activity:	Tissue activity of this recombinase allele
Driver:	Notch1 (mouse) Summary of all recombinase alleles driven by Notch1. Alliance mouse Notch1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:	115 strains or lines available

Original:	J:171829 Liu Z, et al., Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011 Feb 1;121(2):800-8
All:	6 reference(s)