Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Diether Lambrechts
MGI ID:	MGI:5009041
Synonyms:	FLT1WT, stoploxFLT1
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam page

Germline Transmission:	Earliest citation of germline transmission: J:172783
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter) Mutation:    Insertion   Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Flt1 (MGI:95558)   Mutation details: The Flt1 sequence was cloned downstream of an in-frame loxP flanked STOP cassette (lox-neo-lox) and upstream of an IRES sequence followed by the EGFP sequence. In the presence of cre recombinase, the STOP cassette is removed and expression of Flt1 results. Flt1 expression levels are 20% higher in whole dorsal root ganglia compared to wild-type. (J:172783)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	944 strains or lines available

Original:	J:172783 Dhondt J, et al., Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011 May;25(5):1461-73
All:	1 reference(s)