Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3ap1tm1Kuro
Name:	phosphoinositide-3-kinase adaptor protein 1; targeted mutation 1, Tomohiro Kurosaki
MGI ID:	MGI:2178861
Synonyms:	BCAP-
Gene:	Pik3ap1  Location: Chr19:41260980-41373541 bp, - strand  Genetic Position: Chr19, 34.61 cM, cytoband D1
Alliance:	Pik3ap1tm1Kuro page

Germline Transmission:	Earliest citation of germline transmission: J:75075
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette replaced exon 8 of this gene containing 3 sequences encoding YxxM motifs. Northern blot did not detect gene transcripts in homozygous mutant animals. Western blot of splenic B cells from homozygous mutant animals failed to detect protein product. (J:75075)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pik3ap1 Mutation:	50 strains or lines available

Original:	J:75075 Yamazaki T, et al., Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med. 2002 Mar 4;195(5):535-45
All:	15 reference(s)