Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Oprm1tm1Shlz
Name:	opioid receptor, mu 1; targeted mutation 1, Stefan Schulz
MGI ID:	MGI:5000465
Synonyms:	MORS375A
Gene:	Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Alliance:	Oprm1tm1Shlz page

Germline Transmission:	Earliest citation of germline transmission: J:176122
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The coding sequence for serine at codon 375 (TCC) has been replaced using PCR with the coding sequence of alanine (GCC). An FRT flanked PKG-neomycin selection cassette was placed in intron 3. Exons 2 and 3 were also flanked by loxP sites. The selection cassette was subsequently removed by flp-mediated recombination. (J:176122)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:	53 strains or lines available

Original:	J:176122 Grecksch G, et al., Analgesic Tolerance to High-Efficacy Agonists But Not to Morphine Is Diminished in Phosphorylation-Deficient S375A {micro}-Opioid Receptor Knock-In Mice. J Neurosci. 2011 Sep 28;31(39):13890-6
All:	3 reference(s)